Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants

Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants

Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negati...

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Veröffentlicht in:Pediatrics (Evanston) 2012-01, Vol.129 (1), p.e134-e141
Hauptverfasser: Strunk, Tobias, Doherty, Dorota, Jacques, Angela, Simmer, Karen, Richmond, Peter, Kohan, Rolland, Charles, Adrian, Burgner, David
Format: Artikel
Sprache:eng
Schlagworte:
Babies
Bacterial infections
Causes of
Chorioamnionitis
Chorioamnionitis - immunology
Chorioamnionitis - pathology
Female
Health aspects
Humans
Immune response
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - immunology
Infants (Premature)
Obstetric Labor, Premature - etiology
Pediatrics
Perinatal infection
Placenta - pathology
Pregnancy
Premature infants
Premature labor
Regression analysis
Risk factors
Risk Reduction Behavior
Sepsis
Sepsis - immunology
Staphylococcal Infections - immunology
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Zusammenfassung:Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negative staphylococci (CoNS), but the impact of HCA on the risk of LOS is unknown. Eight hundred thirty-eight preterm infants born at
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2010-3493