Complete Genome Sequences of Three Pseudomonas aeruginosa Isolates with Phenotypes of Polymyxin B Adaptation and Inducible Resistance

Clinical "superbug" isolates of Pseudomonas aeruginosa were previously observed to be resistant to several antibiotics, including polymyxin B, and/or to have a distinct, reproducible adaptive polymyxin resistance phenotype, identified by observing "skipped" wells (appearance of e...

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Veröffentlicht in:	Journal of Bacteriology 2012-01, Vol.194 (2), p.529-530
Hauptverfasser:	Boyle, Brian, Fernandez, Lucia, Laroche, Jerome, Kukavica-Ibrulj, Irena, Mendes, Caio M. F, Hancock, Robert W, Levesque, Roger C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology antibiotic resistance Antibiotics Bacteria Bacteriology Drug resistance Drug Resistance, Bacterial - genetics genome Genome Announcements Genome, Bacterial Genomes Genotype & phenotype minimum inhibitory concentration Molecular Sequence Data nucleotide sequences Phenotype polymyxin B Polymyxin B - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - classification Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - physiology
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Beschreibung
Zusammenfassung:	Clinical "superbug" isolates of Pseudomonas aeruginosa were previously observed to be resistant to several antibiotics, including polymyxin B, and/or to have a distinct, reproducible adaptive polymyxin resistance phenotype, identified by observing "skipped" wells (appearance of extra turbid wells) during broth microdilution testing. Here we report the complete assembled draft genome sequences of three such polymyxin resistant P. aeruginosa strains (9BR, 19BR, and 213BR).
ISSN:	0021-9193 1098-5530 1067-8832
DOI:	10.1128/JB.06246-11