CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

Highlights ► CD133+ cells activate cell-cycle-related proteins after irradiation. ► The activation of cell-cycle-related proteins regulate G2/M cell-cycle arrest. ► CD133+ cells show anti-apoptotic and proliferative activities after irradiation. ► The proliferation of CD133+ cells is enhanced via ac...

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Veröffentlicht in:	Cancer letters 2012-02, Vol.315 (2), p.129-137
Hauptverfasser:	Piao, Lian Shu, Hur, Wonhee, Kim, Taek-Kyun, Hong, Sung Woo, Kim, Sung Woo, Choi, Jung Eun, Sung, Pil Soo, Song, Myeong Joon, Lee, Byeong-Chel, Hwang, Daehee, Yoon, Seung Kew
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - genetics Antigens, CD - metabolism Apoptosis Apoptosis - radiation effects Biotechnology Blotting, Western Brain cancer Cancer stem cell Cancer therapies Carcinoma, Hepatocellular - physiopathology CD133 Cell Cycle - radiation effects Cell growth Cell Line, Tumor Cell Proliferation - radiation effects chemotherapy Deoxyribonucleic acid DNA DNA repair Flow Cytometry Gene expression Gene Expression Regulation, Neoplastic - radiation effects Glycoproteins - genetics Glycoproteins - metabolism Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma hepatoma Humans in vivo studies Liver cancer Male Medical prognosis Mice Mice, Inbred BALB C Microarray Microarray Analysis Neoplastic Stem Cells - pathology Neoplastic Stem Cells - radiation effects Neoplastic Stem Cells - transplantation Peptides - genetics Peptides - metabolism radiation resistance Radiation therapy Radiation Tolerance - genetics Radioresistance radiotherapy reactive oxygen species Reactive Oxygen Species - metabolism signal transduction stem cells Studies Tumorigenesis Tumors
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Zusammenfassung:	Highlights ► CD133+ cells activate cell-cycle-related proteins after irradiation. ► The activation of cell-cycle-related proteins regulate G2/M cell-cycle arrest. ► CD133+ cells show anti-apoptotic and proliferative activities after irradiation. ► The proliferation of CD133+ cells is enhanced via activation of ERK/MAPK pathway. ► Liver cancer cells expressing CD133 are associated with radioresistance.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.10.012