Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs

Acyl derivatives of boswellic acids including their epimers were synthesized and screened against a panel of cancer cell lines. One of the lead compounds was found to be an inhibitor of NF-κB and STAT proteins. Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.