Intercellular adhesion molecule, plasma adiponectin and albuminuria in type 2 diabetic patients

Abstract Aims Our study addressed the influence of early inflammatory stages of diabetic kidney disease: leukocyte adhesion and monocyte activation (as assessed by intercellular leukocyte adhesion molecule-ICAM-1 and monocyte chemoatractant protein-MCP-1) on the degree of albuminuria. Plasma levels of adiponectin, a possible anti-inflammatory counteracting mechanism, were also studied in correlation to the above-mentioned cytokines. Methods 79 consecutive type 2 diabetic outpatients and 46 controls were included. Routine laboratory analysis, urinary albumin to creatinine ratio (uACR), plasma adiponectin, plasma ICAM-1 and urinary MPC-1 were assessed. Results In multiple regression ICAM-1 ( p = 0.004) and adiponectin ( p = 0.04) were the main determinants of uACR. Plasma adiponectin positively correlated to ICAM-1 ( p = 0.03, r = 0.24). In albuminuric patients (uACR ≥30 mg/g) plasma adiponectin was significantly higher compared to normoalbuminuric ones (uACR