Low hemoglobin density potential marker of iron availability

Summary Introduction:  Low hemoglobin density (LHD%) is a new parameter provided by Beckman‐Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation This study investigated the reliability of LHD% for the assessment of iron status in the presence of...

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Veröffentlicht in:International journal of laboratory hematology 2012-02, Vol.34 (1), p.47-51
Hauptverfasser: URRECHAGA, E., UNCETA, M., BORQUE, L., ESCANERO, J. F.
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Sprache:eng
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Zusammenfassung:Summary Introduction:  Low hemoglobin density (LHD%) is a new parameter provided by Beckman‐Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation This study investigated the reliability of LHD% for the assessment of iron status in the presence of inflammation. Methods:  Healthy subjects (n = 90) and patients with iron deficiency (IDA, n = 110), chronic kidney disease (CKD, n = 65) and anemia of chronic disease (ACD, n = 85; 24 were iron deficient and 61 were iron sufficient) were analyzed on a LH 780 analyzer (Beckman Coulter Inc., Miami, FL, USA). Independent samples U test and receiver operating characteristic (ROC) curve analysis were applied. To determine the concordance between LHD% and soluble transferrin receptor (sTrR) Cohen’s κ index was calculated. Results:  LHD % values showed no statistical difference in patients with IDA and patients with ACD accompanied with IDA (P = 0.6427); LHD% values in these patients were significantly different (P 
ISSN:1751-5521
1751-553X
DOI:10.1111/j.1751-553X.2011.01355.x