Low hemoglobin density potential marker of iron availability
Summary Introduction: Low hemoglobin density (LHD%) is a new parameter provided by Beckman‐Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation This study investigated the reliability of LHD% for the assessment of iron status in the presence of...
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Veröffentlicht in: | International journal of laboratory hematology 2012-02, Vol.34 (1), p.47-51 |
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Sprache: | eng |
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Zusammenfassung: | Summary
Introduction: Low hemoglobin density (LHD%) is a new parameter provided by Beckman‐Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation
This study investigated the reliability of LHD% for the assessment of iron status in the presence of inflammation.
Methods: Healthy subjects (n = 90) and patients with iron deficiency (IDA, n = 110), chronic kidney disease (CKD, n = 65) and anemia of chronic disease (ACD, n = 85; 24 were iron deficient and 61 were iron sufficient) were analyzed on a LH 780 analyzer (Beckman Coulter Inc., Miami, FL, USA).
Independent samples U test and receiver operating characteristic (ROC) curve analysis were applied. To determine the concordance between LHD% and soluble transferrin receptor (sTrR) Cohen’s κ index was calculated.
Results: LHD % values showed no statistical difference in patients with IDA and patients with ACD accompanied with IDA (P = 0.6427); LHD% values in these patients were significantly different (P |
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ISSN: | 1751-5521 1751-553X |
DOI: | 10.1111/j.1751-553X.2011.01355.x |