Increased risk of nontuberculous mycobacterial infection in asthmatic patients using long-term inhaled corticosteroid therapy

ABSTRACT Background and objective: The risk of pneumonia is increased among COPD patients using inhaled corticosteroids (ICS). However, there is uncertainty regarding the association between long‐term use of ICS and exacerbations of respiratory tract infections among asthmatic patients. Methods: A...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Respirology (Carlton, Vic.) Vic.), 2012-01, Vol.17 (1), p.185-190
Hauptverfasser:	HOJO, MASAYUKI, IIKURA, MOTOYASU, HIRANO, SATOSHI, SUGIYAMA, HARUHITO, KOBAYASHI, NOBUYUKI, KUDO, KOICHIRO
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - adverse effects adverse effect Age Distribution Aged Aged, 80 and over Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - adverse effects Asthma Asthma - drug therapy bronchial asthma Case-Control Studies Chronic obstructive pulmonary disease Corticoids Female fluticasone Humans Infection inhaled corticosteroid Japan - epidemiology Male Middle Aged Mycobacterium Mycobacterium avium-intracellulare Mycobacterium Infections, Nontuberculous - epidemiology Mycobacterium Infections, Nontuberculous - etiology Mycobacterium Infections, Nontuberculous - immunology nontuberculous mycobacterial infection Pneumonia respiratory infection Respiratory tract diseases Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ABSTRACT Background and objective: The risk of pneumonia is increased among COPD patients using inhaled corticosteroids (ICS). However, there is uncertainty regarding the association between long‐term use of ICS and exacerbations of respiratory tract infections among asthmatic patients. Methods: A case‐control nested cohort study was performed to assess the association of asthma with nontuberculous mycobacterium (NTM) infection. Results: Among this cohort of 464 asthmatic patients, 14 experienced complications due to NTM infections, of which eight were caused by Mycobacterium avium‐intracellulare complex, three by M. kansasii, one by M. terrae and the remaining two by unclassifiable scotochromogens. Asthmatic patients with NTM infections were older (67.1 ± 8.6 vs 58.8 ± 12.3 years, P
ISSN:	1323-7799 1440-1843
DOI:	10.1111/j.1440-1843.2011.02076.x