Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells

Cellular differentiation: Using a high‐throughput imaged‐based screen a chemical cocktail that promotes efficient human pluripotent cells (hESCs) differentiation into cardiomyocytes was identified.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2011-11, Vol.50 (47), p.11181-11185
Hauptverfasser:	Gonzalez, Rodolfo, Lee, Jae Wook, Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - chemistry Benzamides - pharmacology cardiomyocytes Cell Culture Techniques Cell Differentiation - drug effects Cell Lineage Cells, Cultured chemically defined differentiation Dioxoles - chemistry Dioxoles - pharmacology Dose-Response Relationship, Drug embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Humans Microscopy, Fluorescence Molecular Structure Morpholines - chemistry Morpholines - pharmacology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism primitive streak Purines - chemistry Purines - pharmacology Pyridines - chemistry Pyridines - pharmacology Pyrimidines - chemistry Pyrimidines - pharmacology Reverse Transcriptase Polymerase Chain Reaction Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Stem cells
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Beschreibung
Zusammenfassung:	Cellular differentiation: Using a high‐throughput imaged‐based screen a chemical cocktail that promotes efficient human pluripotent cells (hESCs) differentiation into cardiomyocytes was identified.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201103909