A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2012-01, Vol.10 (4), p.825-834
Hauptverfasser:	Nieto-García, Olaia, Lago-Santomé, Hugo, Cagide-Fagín, Fernando, Ortiz-Lara, Juan Carlos, Alonso, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amaryllidaceae Alkaloids - chemical synthesis Amaryllidaceae Alkaloids - chemistry Amaryllidaceae Alkaloids - pharmacology Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Cell Line, Tumor Humans Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology Liliaceae - chemistry Lung Neoplasms - drug therapy
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Beschreibung
Zusammenfassung:	A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c1ob06374j