A Case of Myeloma with Hypercalcemia Caused by High Serum Concentrations of both Parathyroid Hormone-related Peptide (PTHrP) and Macrophage Inflammatory Protein-1α (MIP-1α)

A Case of Myeloma with Hypercalcemia Caused by High Serum Concentrations of both Parathyroid Hormone-related Peptide (PTHrP) and Macrophage Inflammatory Protein-1α (MIP-1α)

A 62-year-old woman was admitted with dry mouth, general fatigue, and severe back pain. Biochemistry examination showed extreme hypercalcemia (21.2 mg/dL). Bone marrow examination was negative, but needle biopsy of a metastatic lung tumor revealed abnormal plasma cells; thus, multiple myeloma stage...

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Veröffentlicht in:Internal Medicine 2011, Vol.50(24), pp.2993-2996
Hauptverfasser: Shimizu, Hiroaki, Monden, Tsuyoshi, Tomotsune, Takanori, Nakatani, Yuki, Domeki, Nozomi, Matsumura, Mihoko, Jojima, Teruo, Kawagoe, Yoshiaki, Kasai, Kikuo
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Bone Density Conservation Agents - administration & dosage
Calcitonin - administration & dosage
Calcium - blood
Chemokine CCL3 - blood
Dexamethasone - administration & dosage
Diphosphonates - administration & dosage
Doxorubicin - administration & dosage
Female
Humans
humoral hypercalcemia of malignancy
Hypercalcemia - blood
Hypercalcemia - drug therapy
Hypercalcemia - etiology
local osteolytic hypercalcemia
macrophage inflammatory protein-1α
Middle Aged
Multiple Myeloma - blood
Multiple Myeloma - complications
Multiple Myeloma - diagnosis
Multiple Myeloma - drug therapy
Pamidronate
parathyroid hormone-related peptide
Parathyroid Hormone-Related Protein - blood
Vincristine - administration & dosage
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Zusammenfassung:A 62-year-old woman was admitted with dry mouth, general fatigue, and severe back pain. Biochemistry examination showed extreme hypercalcemia (21.2 mg/dL). Bone marrow examination was negative, but needle biopsy of a metastatic lung tumor revealed abnormal plasma cells; thus, multiple myeloma stage III-A was finally diagnosed. Serum concentrations of both parathyroid hormone-related peptide (PTHrP) and macrophage inflammatory protein-1α (MIP-1α) were markedly elevated (PTHrP 7.2 pmol/L, normal
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.50.6096