Prognosis for Live Birth in Women With Recurrent Miscarriage: What Is the Best Measure of Success?
OBJECTIVE:To establish a method of estimating the proportion of women with a subsequent live birth after a well-defined time period in an open cohort of women referred to a tertiary recurrent miscarriage clinic. METHODS:We performed a descriptive cohort study with register-based follow-up at a terti...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2012-01, Vol.119 (1), p.37-43 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Lund, Marie Kamper-Jørgensen, Mads Nielsen, Henriette Svarre Lidegaard, Øjvind Andersen, Anne-Marie Nybo Christiansen, Ole Bjarne |
| description | OBJECTIVE:To establish a method of estimating the proportion of women with a subsequent live birth after a well-defined time period in an open cohort of women referred to a tertiary recurrent miscarriage clinic.
METHODS:We performed a descriptive cohort study with register-based follow-up at a tertiary center for investigation and treatment of recurrent miscarriage in Denmark. All women with primary or secondary recurrent miscarriage referred to the clinic from 1986 to 2008 were included in the study (n=987). Main outcome measures were age-specific and miscarriage-specific proportions of women with a live birth after the first consultation and similar hazard ratios compared with the prognosis in women aged 30–34 years with three miscarriages before the first consultation.
RESULTS:Five years after the first consultation, 66.7% (95% confidence interval [CI] 63.7–69.7) had achieved a live birth, increasing to 71.1% (95% CI 68.0–74.2) 15 years after the first consultation. There was a significantly decreased chance of at least one subsequent live birth with increasing maternal age (log-rank P |
| doi_str_mv | 10.1097/AOG.0b013e31823c0413 |
| format | Article |
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METHODS:We performed a descriptive cohort study with register-based follow-up at a tertiary center for investigation and treatment of recurrent miscarriage in Denmark. All women with primary or secondary recurrent miscarriage referred to the clinic from 1986 to 2008 were included in the study (n=987). Main outcome measures were age-specific and miscarriage-specific proportions of women with a live birth after the first consultation and similar hazard ratios compared with the prognosis in women aged 30–34 years with three miscarriages before the first consultation.
RESULTS:Five years after the first consultation, 66.7% (95% confidence interval [CI] 63.7–69.7) had achieved a live birth, increasing to 71.1% (95% CI 68.0–74.2) 15 years after the first consultation. There was a significantly decreased chance of at least one subsequent live birth with increasing maternal age (log-rank P<.01) and increasing number of miscarriages (log-rank P<.01) at first consultation.
CONCLUSION:Approximately two thirds of women with recurrent miscarriage referred to a tertiary center succeed in having at least one live birth within 5 years after their first consultation. Our study allows for a descriptive overview of the course of live birth outcome in women with recurrent miscarriage, but not for evaluation of the effect of treatment.
LEVEL OF EVIDENCE:III</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e31823c0413</identifier><identifier>PMID: 22183209</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>Hagerstown, MD: The American College of Obstetricians and Gynecologists</publisher><subject>Abortion, Habitual - diagnosis ; Abortion, Habitual - epidemiology ; Adult ; Biological and medical sciences ; Cohort Studies ; Denmark - epidemiology ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Live Birth - epidemiology ; Medical sciences ; Middle Aged ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prognosis ; Young Adult</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2012-01, Vol.119 (1), p.37-43</ispartof><rights>2012 The American College of Obstetricians and Gynecologists</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3307-de4bf412e2b194093c9d81a9db7d0b6f57be4807edc19054fd6d46e76ace91243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4035,4036,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25505961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22183209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lund, Marie</creatorcontrib><creatorcontrib>Kamper-Jørgensen, Mads</creatorcontrib><creatorcontrib>Nielsen, Henriette Svarre</creatorcontrib><creatorcontrib>Lidegaard, Øjvind</creatorcontrib><creatorcontrib>Andersen, Anne-Marie Nybo</creatorcontrib><creatorcontrib>Christiansen, Ole Bjarne</creatorcontrib><title>Prognosis for Live Birth in Women With Recurrent Miscarriage: What Is the Best Measure of Success?</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVE:To establish a method of estimating the proportion of women with a subsequent live birth after a well-defined time period in an open cohort of women referred to a tertiary recurrent miscarriage clinic.
METHODS:We performed a descriptive cohort study with register-based follow-up at a tertiary center for investigation and treatment of recurrent miscarriage in Denmark. All women with primary or secondary recurrent miscarriage referred to the clinic from 1986 to 2008 were included in the study (n=987). Main outcome measures were age-specific and miscarriage-specific proportions of women with a live birth after the first consultation and similar hazard ratios compared with the prognosis in women aged 30–34 years with three miscarriages before the first consultation.
RESULTS:Five years after the first consultation, 66.7% (95% confidence interval [CI] 63.7–69.7) had achieved a live birth, increasing to 71.1% (95% CI 68.0–74.2) 15 years after the first consultation. There was a significantly decreased chance of at least one subsequent live birth with increasing maternal age (log-rank P<.01) and increasing number of miscarriages (log-rank P<.01) at first consultation.
CONCLUSION:Approximately two thirds of women with recurrent miscarriage referred to a tertiary center succeed in having at least one live birth within 5 years after their first consultation. Our study allows for a descriptive overview of the course of live birth outcome in women with recurrent miscarriage, but not for evaluation of the effect of treatment.
LEVEL OF EVIDENCE:III</description><subject>Abortion, Habitual - diagnosis</subject><subject>Abortion, Habitual - epidemiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Live Birth - epidemiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prognosis</subject><subject>Young Adult</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkW9rFDEQxkNRemfrNxDJG_HVtpM_u9n4RmrRtnBSaSvnu5DNznaje5ua7Fr89ua404IQMkzm98wMTwh5xeCEgVanZ9cXJ9AAEyhYzYUDycQBWbJaiYIL8e0ZWQJwXahaygV5kdJ3AGCVFodkwTmrBQe9JM2XGO7HkHyiXYh05X8h_eDj1FM_0nXYYL59zm7QzTHiONHPPjkbo7f3-I6uezvRq0SnPssw5SraNEekoaO3s3OY0vtj8ryzQ8KX-3hEvn76eHd-WayuL67Oz1aFEwJU0aJsOsk48oZpCVo43dbM6rZRLTRVV6oGZQ0KW8c0lLJrq1ZWqCrrUDMuxRF5u-v7EMPPOS9jNnlVHAY7YpiTyRBXolIik3JHuhhSitiZh-g3Nv42DMzWXJPNNf-bm2Wv9wPmZoPtP9FfNzPwZg_Y7NHQRTs6n564soRSV-xp_mMYJozpxzA_YjQ92mHqTf4mqHgJBQeWT86K7ZMSfwBXc5Gt</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Lund, Marie</creator><creator>Kamper-Jørgensen, Mads</creator><creator>Nielsen, Henriette Svarre</creator><creator>Lidegaard, Øjvind</creator><creator>Andersen, Anne-Marie Nybo</creator><creator>Christiansen, Ole Bjarne</creator><general>The American College of Obstetricians and Gynecologists</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Prognosis for Live Birth in Women With Recurrent Miscarriage: What Is the Best Measure of Success?</title><author>Lund, Marie ; Kamper-Jørgensen, Mads ; Nielsen, Henriette Svarre ; Lidegaard, Øjvind ; Andersen, Anne-Marie Nybo ; Christiansen, Ole Bjarne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3307-de4bf412e2b194093c9d81a9db7d0b6f57be4807edc19054fd6d46e76ace91243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion, Habitual - diagnosis</topic><topic>Abortion, Habitual - epidemiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Denmark - epidemiology</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Live Birth - epidemiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prognosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lund, Marie</creatorcontrib><creatorcontrib>Kamper-Jørgensen, Mads</creatorcontrib><creatorcontrib>Nielsen, Henriette Svarre</creatorcontrib><creatorcontrib>Lidegaard, Øjvind</creatorcontrib><creatorcontrib>Andersen, Anne-Marie Nybo</creatorcontrib><creatorcontrib>Christiansen, Ole Bjarne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lund, Marie</au><au>Kamper-Jørgensen, Mads</au><au>Nielsen, Henriette Svarre</au><au>Lidegaard, Øjvind</au><au>Andersen, Anne-Marie Nybo</au><au>Christiansen, Ole Bjarne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis for Live Birth in Women With Recurrent Miscarriage: What Is the Best Measure of Success?</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>119</volume><issue>1</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVE:To establish a method of estimating the proportion of women with a subsequent live birth after a well-defined time period in an open cohort of women referred to a tertiary recurrent miscarriage clinic.
METHODS:We performed a descriptive cohort study with register-based follow-up at a tertiary center for investigation and treatment of recurrent miscarriage in Denmark. All women with primary or secondary recurrent miscarriage referred to the clinic from 1986 to 2008 were included in the study (n=987). Main outcome measures were age-specific and miscarriage-specific proportions of women with a live birth after the first consultation and similar hazard ratios compared with the prognosis in women aged 30–34 years with three miscarriages before the first consultation.
RESULTS:Five years after the first consultation, 66.7% (95% confidence interval [CI] 63.7–69.7) had achieved a live birth, increasing to 71.1% (95% CI 68.0–74.2) 15 years after the first consultation. There was a significantly decreased chance of at least one subsequent live birth with increasing maternal age (log-rank P<.01) and increasing number of miscarriages (log-rank P<.01) at first consultation.
CONCLUSION:Approximately two thirds of women with recurrent miscarriage referred to a tertiary center succeed in having at least one live birth within 5 years after their first consultation. Our study allows for a descriptive overview of the course of live birth outcome in women with recurrent miscarriage, but not for evaluation of the effect of treatment.
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| ispartof | Obstetrics and gynecology (New York. 1953), 2012-01, Vol.119 (1), p.37-43 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Abortion, Habitual - diagnosis Abortion, Habitual - epidemiology Adult Biological and medical sciences Cohort Studies Denmark - epidemiology Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Live Birth - epidemiology Medical sciences Middle Aged Pregnancy Pregnancy. Fetus. Placenta Prognosis Young Adult |
| title | Prognosis for Live Birth in Women With Recurrent Miscarriage: What Is the Best Measure of Success? |
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