Enhanced Effect of Platelet‐Rich Plasma Containing a New Carrier on Hair Growth

BACKGROUND Treatments for alopecia are in high demand, but not all are safe and reliable. Dalteparin and protamine microparticles (D/P MPs) can effectively carry growth factors (GFs) in platelet‐rich plasma (PRP). OBJECTIVE To identify the effects of PRP‐containing D/P MPs (PRP&D/P MPs) on hair growth. METHODS & MATERIALS Participants were 26 volunteers with thin hair who received five local treatments of 3 mL of PRP&D/P MPs (13 participants) or PRP and saline (control, 13 participants) at 2‐ to 3‐week intervals and were evaluated for 12 weeks. Injected areas comprised frontal or parietal sites with lanugo‐like hair. Experimental and control areas were photographed. Consenting participants underwent biopsies for histologic examination. RESULTS D/P MPs bind to various GFs contained in PRP. Significant differences were seen in hair cross‐section but not in hair numbers in PRP and PRP&D/P MP injections. The addition of D/P MPs to PRP resulted in significant stimulation in hair cross‐section. Microscopic findings showed thickened epithelium, proliferation of collagen fibers and fibroblasts, and increased vessels around follicles. CONCLUSION PRP&D/P MPs and PRP facilitated hair growth but D/P MPs provided additional hair growth. The authors have indicated no significant interest with commercial supporters.