Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

A biomimetic substrate for cell‐culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

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Veröffentlicht in:Advanced materials (Weinheim) 2011-12, Vol.23 (48), p.5785-5791
Hauptverfasser: Chen, Aaron, Lieu, Deborah K., Freschauf, Lauren, Lew, Valerie, Sharma, Himanshu, Wang, Jiaxian, Nguyen, Diep, Karakikes, Ioannis, Hajjar, Roger J., Gopinathan, Ajay, Botvinick, Elliot, Fowlkes, Charless C., Li, Ronald A., Khine, Michelle
Format: Artikel
Sprache:eng
Schlagworte:
action potential propagation
Action Potentials
Animals
Biomimetics
Cell Differentiation
Cells, Cultured
contact guidance
Embryonic Stem Cells - cytology
Equipment Design
Flow Cytometry - methods
human embryonic stem cell derived cardiomyocytes
Humans
Materials Testing
Mice
Myocardium - cytology
Myocytes, Cardiac - cytology
Rats
Stem Cells - cytology
Surface Properties
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Zusammenfassung:A biomimetic substrate for cell‐culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201103463