Expanding the Optical Trapping Range of Lipid Vesicles to the Nanoscale

Expanding the Optical Trapping Range of Lipid Vesicles to the Nanoscale

Small unilamellar lipid vesicles with diameters down to 50 nm enclosing high refractive index sucrose cores can be optically trapped individually in three dimensions using a focused laser beam. Combined optical trapping and confocal microscopy allows for simultaneous quantitative measurements of the...

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Veröffentlicht in:Nano letters 2011-12, Vol.11 (12), p.5431-5437
Hauptverfasser: Bendix, Poul M, Oddershede, Lene B
Format: Artikel
Sprache:eng
Schlagworte:
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Condensed matter: structure, mechanical and thermal properties
Confocal
Exact sciences and technology
Lipids
Lipids - chemistry
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Microscopy
Nanoparticles - chemistry
Nanostructure
Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation
Optical properties of low-dimensional, mesoscopic, and nanoscale materials and structures
Optical trapping
Particle Size
Physics
Position measurement
Refractometry
Sucrose
Sucrose - chemistry
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Three dimensional
Unilamellar Liposomes - chemistry
Vesicles
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Zusammenfassung:Small unilamellar lipid vesicles with diameters down to 50 nm enclosing high refractive index sucrose cores can be optically trapped individually in three dimensions using a focused laser beam. Combined optical trapping and confocal microscopy allows for simultaneous quantitative measurements of the forces exerted on individual vesicles and of their size and shape. The position of individual vesicles in three dimensions is measured with nanometer spatial and ∼10 μs temporal resolution.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl203200g