A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C–H Activation

A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C–H Activation

A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C–H activation.

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Veröffentlicht in:Organic letters 2011-12, Vol.13 (24), p.6500-6503
Hauptverfasser: Son, Young Wook, Kwon, Tae Hui, Lee, Jae Kyun, Pae, Ae Nim, Lee, Jae Yeol, Cho, Yong Seo, Min, Sun-Joon
Format: Artikel
Sprache:eng
Schlagworte:
Cyclization
Molecular Structure
Oxidation-Reduction
Silanes - chemistry
Tetrabenazine - analogs & derivatives
Tetrabenazine - chemical synthesis
Tetrabenazine - chemistry
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Zusammenfassung:A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C–H activation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202792q