Regiospecific Synthesis of 1,2-Disubstituted (Hetero)aryl Fused Imidazoles with Tunable Fluorescent Emission

A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. Thes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2011-12, Vol.13 (24), p.6516-6519
Hauptverfasser:	Zhao, Dongbing, Hu, Junyi, Wu, Ningjie, Huang, Xiaolei, Qin, Xurong, Lan, Jingbo, You, Jingsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Catalysis Combinatorial Chemistry Techniques Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Imidazoles - chemical synthesis Imidazoles - chemistry Molecular Structure Palladium - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol202807d