Clinical efficacy of arbekacin for Gram-negative bacteria

Abstract In an analysis of methicillin-resistant Staphylococcus aureus (MRSA) infected patients treated with arbekacin (ABK) only, Gram-negative bacteria (GNB) that were inhibited by low minimal inhibitory concentrations (MICs) of amikacin (AMK) or gentamycin (GM) were eradicated by the end of the A...

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Veröffentlicht in:	Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2011-12, Vol.17 (6), p.876-879
Hauptverfasser:	Hamada, Yukihiro, Kuroyama, Masakazu, Tamura, Kazuyoshi, Yago, Kazuo, Koyama, Ikumi, Sunakawa, Keisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amikacin Anti-Bacterial Agents - therapeutic use Arbekacin Blood concentration level Coinfection - drug therapy Coinfection - microbiology Dibekacin - analogs & derivatives Dibekacin - therapeutic use Drug resistance Female Gram-negative bacteria Gram-negative bacteria (GNB) Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - isolation & purification Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Hematology, Oncology and Palliative Medicine Humans Infectious Diseases Male Medical Microbiology Medicine Medicine & Public Health Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Middle Aged Minimal inhibitory concentration (MIC) Minimum inhibitory concentration Mixed infection Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Virology
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Zusammenfassung:	Abstract In an analysis of methicillin-resistant Staphylococcus aureus (MRSA) infected patients treated with arbekacin (ABK) only, Gram-negative bacteria (GNB) that were inhibited by low minimal inhibitory concentrations (MICs) of amikacin (AMK) or gentamycin (GM) were eradicated by the end of the ABK treatment. On the other hand, GNB that were only inhibited by high MICs of AMK or GM persisted until the end of treatment with ABK only. Thus, ABK can be expected to be effective even in cases of mixed infection with GNB and MRSA.
ISSN:	1341-321X 1437-7780
DOI:	10.1007/s10156-011-0262-x