Clinical significance and prognosis of MYC translocation in diffuse large B-cell lymphoma

Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large B‐cell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed using interpha...

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Veröffentlicht in:	Hematological oncology 2011-12, Vol.29 (4), p.185-189
Hauptverfasser:	Zhang, Hong Wei, Chen, Zhen Wen, Li, Su Hong, Bai, Wei, Cheng, Niu Liang, Wang, Jin Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Chinese DLBCL chromosome translocation Female FISH Genes, myc Humans Immunophenotyping Kaplan-Meier Estimate Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Male Middle Aged MYC gene Prognosis survival analysis Translocation, Genetic
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Zusammenfassung:	Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large B‐cell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed using interphase fluorescent in situ hybridization. Immunophenotyping analysis (CD20, CD3, CD10, Bcl‐6, Mum‐1) was also performed. MYC translocation was identified in 13 (12.3%) out of 106 cases. All MYC+ DLBCLs showed a non‐germinal center B‐cell type. MYC+ DLBCLs showed significantly poorer overall survival (OS) and progression‐free survival, with a median OS and progression‐free survival time of 4.7 and 3.2 months, respectively (p
ISSN:	0278-0232 1099-1069
DOI:	10.1002/hon.991