Active immunization against IL-23p19 improves experimental arthritis

Highlights ► Murine IL-23p19 subunit has been modeled in silico. ► Peptides from IL-23p19 were coupled to KLH and used as vaccine for CIA. ► Mice vaccinated against IL-23p19 peptide developed less arthritis than controls. ► Targeting IL-23p19 might constitute a promising therapeutic approach in arth...

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Veröffentlicht in:	Vaccine 2011-11, Vol.29 (50), p.9329-9336
Hauptverfasser:	Ratsimandresy, Rojo Anthony, Duvallet, Emilie, Assier, Eric, Semerano, Luca, Delavallée, Laure, Bessis, Natacha, Zagury, Jean-François, Boissier, Marie-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Allergy and Immunology animal models Animals antibodies Antibodies, Neutralizing - immunology Antibody Formation Applied microbiology Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - immunology Arthritis, Experimental - therapy Autoimmune diseases Binding Sites bioinformatics Biological and medical sciences cattle collagen Colleges & universities Cytokines Cytokines - immunology Disease enzyme-linked immunosorbent assay Female Freund's Adjuvant - pharmacology Fundamental and applied biological sciences. Psychology Hemocyanins - pharmacology IL-23p19 Immunization inflammation interleukin-10 interleukin-12 interleukin-17 interleukin-1beta interleukin-23 Interleukin-23 Subunit p19 - immunology Lipids - pharmacology Lymphocytes Male messenger RNA Mice Mice, Inbred DBA Microbiology Neutralization Tests Peptides Protein Structure, Tertiary Rabbits reverse transcriptase polymerase chain reaction Rheumatoid arthritis Spleen Spleen - cytology Spleen - immunology T-lymphocytes T-Lymphocytes - immunology tumor necrosis factor-alpha Vaccination vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - immunology
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Beschreibung
Zusammenfassung:	Highlights ► Murine IL-23p19 subunit has been modeled in silico. ► Peptides from IL-23p19 were coupled to KLH and used as vaccine for CIA. ► Mice vaccinated against IL-23p19 peptide developed less arthritis than controls. ► Targeting IL-23p19 might constitute a promising therapeutic approach in arthritis.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.09.134