Immunization with rP22 induces protective immunity against Schistosoma mansoni : Effects on granuloma down-modulation and cytokine production

Highlights ► The recombinant P22 protein is a protective antigen against schistosomiasis in mice. ► rP22 is a tegument protein localized on the surface of S. mansoni adult worms. ► Mice immunization with rP22 induced a reduction in worm burden and in hepatic eggs. ► rP22 vaccination also induced a s...

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Veröffentlicht in:	Immunology letters 2011-12, Vol.141 (1), p.123-133
Hauptverfasser:	Rezende, Cíntia M.F, Silva, Marina R, Santos, Íria G.D, Silva, Gerluza A.B, Gomes, Dawidson A, Goes, Alfredo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Cytokine profile Female Granuloma - immunology Granuloma - prevention & control Granuloma down-modulation Helminth Proteins - administration & dosage Helminth Proteins - genetics Helminth Proteins - immunology Humans Hypersensitivity - immunology Interferon-gamma - analysis Interferon-gamma - immunology Interleukin-10 - analysis Interleukin-10 - immunology Interleukin-4 - analysis Interleukin-4 - immunology Liver - pathology Mice Mice, Inbred C57BL Public Health Rabbits Recombinant rP22 Schistosoma mansoni Schistosoma mansoni - genetics Schistosoma mansoni - immunology Schistosomiasis mansoni - immunology Schistosomiasis mansoni - prevention & control Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - immunology Vaccination Vaccine Vaccines - administration & dosage Vaccines - immunology
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Beschreibung
Zusammenfassung:	Highlights ► The recombinant P22 protein is a protective antigen against schistosomiasis in mice. ► rP22 is a tegument protein localized on the surface of S. mansoni adult worms. ► Mice immunization with rP22 induced a reduction in worm burden and in hepatic eggs. ► rP22 vaccination also induced a significant reduction in liver granuloma size. ► Protection was associated with elevated production of IFN-γ, TNF-α, and IL-10.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2011.09.003