The genetic network controlling plasma cell differentiation

The genetic network controlling plasma cell differentiation

Highlights ► Terminal differentiation of B cells to plasma cells occurs in a stochastic manner. ► A gene regulatory network controls plasma cell differentiation. ► Gene expression in B cells and plasma cells is maintained by distinct transcription factors. ► Blimp1 and Irf4 are dose-dependent regula...

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Veröffentlicht in:Seminars in immunology 2011-10, Vol.23 (5), p.341-349
Hauptverfasser: Nutt, Stephen L, Taubenheim, Nadine, Hasbold, Jhagvaral, Corcoran, Lynn M, Hodgkin, Philip D
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
B cell
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Cell Differentiation
Gene regulatory network
Gene Regulatory Networks
Humans
Models, Biological
Plasma cell
Plasma Cells - cytology
Transcription factor
Transcription, Genetic
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Beschreibung
Zusammenfassung:Highlights ► Terminal differentiation of B cells to plasma cells occurs in a stochastic manner. ► A gene regulatory network controls plasma cell differentiation. ► Gene expression in B cells and plasma cells is maintained by distinct transcription factors. ► Blimp1 and Irf4 are dose-dependent regulators of plasma cells.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2011.08.010