Polymersomes enhance the immunogenicity of influenza subunit vaccine

Polymersomes enhance the immunogenicity of influenza subunit vaccine

In this study poly([gamma]-benzyl-l-glutamate)-K (PBLG50-K) polymersomes are tested as an immune adjuvant for an antigen, influenza hemagglutinin (HA). The polymersomes were prepared according to a solvent removal method and loaded with HA antigens via adsorption. The immunogenicity of the resulting...

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Veröffentlicht in:Polymer chemistry 2011-01, Vol.2 (7), p.1482-1485
Hauptverfasser: Barnier Quer, Christophe, Robson Marsden, Hana, Romeijn, Stefan, Zope, Harshal, Kros, Alexander, Jiskoot, Wim
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants
Adsorption
Hemagglutinins
Hybrids
Immune response
Immunogenicity
Influenza
Solvents
Vaccines
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Zusammenfassung:In this study poly([gamma]-benzyl-l-glutamate)-K (PBLG50-K) polymersomes are tested as an immune adjuvant for an antigen, influenza hemagglutinin (HA). The polymersomes were prepared according to a solvent removal method and loaded with HA antigens via adsorption. The immunogenicity of the resulting hybrid assemblies was tested in vivo, resulting in an improvement of the immune response for the influenza antigen co-administered with the polymersomes.
ISSN:1759-9954
1759-9962
DOI:10.1039/c1py00010a