Lest we forget you — methylene blue
Abstract Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders...
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| Veröffentlicht in: | Neurobiology of aging 2011-12, Vol.32 (12), p.2325.e7-2325.e16 |
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| container_end_page | 2325.e16 |
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| container_issue | 12 |
| container_start_page | 2325.e7 |
| container_title | Neurobiology of aging |
| container_volume | 32 |
| creator | Schirmer, R. Heiner Adler, Heike Pickhardt, Marcus Mandelkow, Eckhard |
| description | Abstract Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders such as Alzheimer's disease (AD), possibly through its inhibition of the aggregation of tau protein. Here we review the history and medical applications of MB, with emphasis on recent developments. |
| doi_str_mv | 10.1016/j.neurobiolaging.2010.12.012 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2011-12, Vol.32 (12), p.2325.e7-2325.e16 |
| issn | 0197-4580 1558-1497 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alzheimer Disease - diagnosis Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Animals Antimalarials - chemistry Antimalarials - therapeutic use History Humans Internal Medicine malaria therapy Medical application Methylene blue Methylene Blue - chemistry Methylene Blue - therapeutic use Neurology prodrug of azure B tau aggregation inhibitor tau Proteins - metabolism |
| title | Lest we forget you — methylene blue |
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