Lest we forget you — methylene blue

Abstract Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders...

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Veröffentlicht in:Neurobiology of aging 2011-12, Vol.32 (12), p.2325.e7-2325.e16
Hauptverfasser: Schirmer, R. Heiner, Adler, Heike, Pickhardt, Marcus, Mandelkow, Eckhard
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders such as Alzheimer's disease (AD), possibly through its inhibition of the aggregation of tau protein. Here we review the history and medical applications of MB, with emphasis on recent developments.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2010.12.012