Leukotriene D4 Induces Bronchoconstriction in Man

The effect of leukotriene D4 (LTD4) on lung function was investigated in a controlled study on four normal subjects. A pronounced decrease in airflow was found after inhalation of less than 0.5 nmol, and was most pronounced in the variables generally accepted as indicators of the function of the sma...

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Veröffentlicht in:	Allergy (Copenhagen) 1983-08, Vol.38 (6), p.441-443
Hauptverfasser:	Bisgaard, Hans, Groth, Steffen, Dirksen, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	asthma Asthma - physiopathology Biological and medical sciences Bronchi - drug effects Fundamental and applied biological sciences. Psychology Humans leukotriene D4 lung function tests Prostaglandins. Arachidonic acid metabolites Pulmonary Ventilation - drug effects SRS-A - immunology SRS-A - pharmacology Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	The effect of leukotriene D4 (LTD4) on lung function was investigated in a controlled study on four normal subjects. A pronounced decrease in airflow was found after inhalation of less than 0.5 nmol, and was most pronounced in the variables generally accepted as indicators of the function of the small airways. No subjective symptoms were experienced.
ISSN:	0105-4538 1398-9995
DOI:	10.1111/j.1398-9995.1983.tb05087.x