Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors

Highlights ► DBV's anti-nociceptive effect involves suppression of spinal astrocyte activation. ► DBV-induced astrocyte inhibition is mediated by spinal alpha-2A and alpha-2C adrenoceptors. ► Astrocyte modulation by DBV is potentiated by i.t. administration of fluorocitrate.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2011-11, Vol.86 (5), p.412-421
Hauptverfasser:	Kang, Suk-Yun, Kim, Chi-Young, Roh, Dae-Hyun, Yoon, Seo-Yeon, Park, Ji-Ho, Lee, Hye-Jung, Beitz, Alvin J, Lee, Jang-Hern
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Acupuncture Points Adrenergic alpha-2 Receptor Antagonists - pharmacology Adrenergic receptors Alpha-2 adrenoceptor Analgesics - pharmacology Analgesics - therapeutic use Animals Antagonists Anti-nociceptive effect Astrocyte Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Bee venom Bee Venoms - administration & dosage Bee Venoms - pharmacology Citrates - administration & dosage Citrates - pharmacology Formaldehyde - pharmacology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Idazoxan - pharmacology Imidazoles - pharmacology Inflammation Injections, Spinal Isoindoles - pharmacology Male Mice Mice, Inbred ICR Neurology Pain - chemically induced Pain - drug therapy Pain Management - methods Pain Measurement - methods Pain perception Receptors, Adrenergic, alpha-2 - metabolism Spinal Cord - cytology Stimulation, Chemical Venom
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Beschreibung
Zusammenfassung:	Highlights ► DBV's anti-nociceptive effect involves suppression of spinal astrocyte activation. ► DBV-induced astrocyte inhibition is mediated by spinal alpha-2A and alpha-2C adrenoceptors. ► Astrocyte modulation by DBV is potentiated by i.t. administration of fluorocitrate.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.08.012