Risk of convulsions in children after monovalent H1N1 (2009) and trivalent influenza vaccines: A database study

Highlights ► The risk of convulsions in the week after influenza vaccination was assessed. ► No increased risk was found after trivalent influenza vaccine. ► No increased risk was found after single dose adjuvanted monovalent H1N1 vaccine. ► Signal of an elevated risk after the second dose of monova...

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Veröffentlicht in:	Vaccine 2011-11, Vol.29 (51), p.9467-9472
Hauptverfasser:	Stowe, Julia, Andrews, Nick, Bryan, Phil, Seabroke, Suzie, Miller, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Age Allergy and Immunology Child Child, Preschool Children Clinical trials Codes Convulsions Data processing Female Fever Fever - etiology Humans Immunization Immunogenicity Infant Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza vaccine Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - prevention & control Male monitoring Monovalent H1N1 vaccine pandemic pandemics risk seizures Seizures - etiology Self-controlled case-series method Statistical methods Swine flu vaccination Vaccine associated adverse events Vaccines virion Virions
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Beschreibung
Zusammenfassung:	Highlights ► The risk of convulsions in the week after influenza vaccination was assessed. ► No increased risk was found after trivalent influenza vaccine. ► No increased risk was found after single dose adjuvanted monovalent H1N1 vaccine. ► Signal of an elevated risk after the second dose of monovalent H1N1 influenza vaccine. ► Extension of TIV to healthy children may reduce convulsions by preventing influenza.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.10.029