Neurocognitive function in patients with β-thalassemia major

Neurocognitive function in patients with β-thalassemia major

Background:  Children with β‐thalassemia major (β‐TM) have multiple risk factors for developing cognitive impairment. The aim of the present study was to evaluate cognitive function in patients with β‐TM. Methods:  Twenty children with β‐TM were enrolled into the study and were compared with a contr...

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Veröffentlicht in:Pediatrics international 2011-08, Vol.53 (4), p.519-523
Hauptverfasser: Duman, Ozgur, Arayici, Sema, Fettahoglu, Cigil, Eryilmaz, Nurkan, Ozkaynak, Sibel, Yesilipek, Akif, Hazar, Volkan
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
anemia
Auditory Perceptual Disorders - diagnosis
Auditory Perceptual Disorders - etiology
beta-Thalassemia - physiopathology
beta-Thalassemia - psychology
Case-Control Studies
Child
Children
cognition
Cognition - physiology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
cognitive ability
Event-Related Potentials, P300
Evoked Potentials
Evoked Potentials, Auditory
Female
Humans
Intelligence
Male
mismatch negativity
Neuropsychological Tests
P300
Perceptual Disorders - diagnosis
Perceptual Disorders - etiology
Risk factors
Visual Perception
β-thalassemia
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Zusammenfassung:Background:  Children with β‐thalassemia major (β‐TM) have multiple risk factors for developing cognitive impairment. The aim of the present study was to evaluate cognitive function in patients with β‐TM. Methods:  Twenty children with β‐TM were enrolled into the study and were compared with a control group consisting of 21 healthy children. All participants were evaluated with neuropsychological tests and event‐related potentials (ERP). Results:  All of the participants had normal IQ scores, but the patient group had significantly lower full‐scale, performance, and verbal IQs compared with the control group (P 
ISSN:1328-8067
1442-200X
DOI:10.1111/j.1442-200X.2010.03279.x