Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo

Highlights ► We investigated the antitumor activity and its immunological mechanisms of SEP in H22-bearing mice. ► SEP effectively inhibited hepatocellular carcinoma via enhancement of splenocyte proliferation, T cell numbers and activity. ► SEP also elevated IL-2 and TNF-α secretion as well as IgA,...

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Veröffentlicht in:	Immunology letters 2011-12, Vol.141 (1), p.74-82
Hauptverfasser:	Wang, Mengyu, Wang, Hui, Tang, Ying, Kang, Di, Gao, Yu, Ke, Mengyun, Dou, Jie, Xi, Tao, Zhou, Changlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antineoplastic Agents - pharmacology Antitumor Carcinoma Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - therapy CD4 antigen CD8 antigen Cell Line, Tumor Cell Proliferation Cytokines Cytotoxicity Eggs Extracellular signal-regulated kinase Hepatocellular carcinoma Hepatoma Immune response Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins - blood Immunoregulation Immunosuppressive agents Interleukin 2 Interleukin-2 - analysis Liver Neoplasms - immunology Liver Neoplasms - therapy Lymphocytes T Male Mice NF-AT protein Phosphorylation Polysaccharide Polysaccharides Polysaccharides - immunology Polysaccharides - pharmacology Promoters Somatosensory evoked potentials Spleen - cytology Spleen - immunology Splenocytes Strongylocentrotus - immunology Strongylocentrotus nudus T-Lymphocytes - immunology T-Lymphocytes - metabolism Transcription Tumor cell lines Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - analysis Tumors
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Beschreibung
Zusammenfassung:	Highlights ► We investigated the antitumor activity and its immunological mechanisms of SEP in H22-bearing mice. ► SEP effectively inhibited hepatocellular carcinoma via enhancement of splenocyte proliferation, T cell numbers and activity. ► SEP also elevated IL-2 and TNF-α secretion as well as IgA, IgM and IgG levels in the serum. ► Erk phosphorylation and NFAT promoter activated by SEP promoted the transcription and expression of downstream gene IL-2.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2011.08.001