AA amyloidosis associated with hepatitis B

We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the pre...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2011-07, Vol.26 (7), p.2407-2412
Hauptverfasser:	Saha, Abhijeet, Theis, Jason D., Vrana, Julie A., Dubey, Nand K., Batra, Vineeta V., Sethi, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloidosis - complications Amyloidosis - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Child Chromatography, Liquid Emergency and intensive care: renal failure. Dialysis management Hepatitis B - complications Hepatitis B - metabolism Hepatitis B virus - pathogenicity Human viral diseases Humans Infectious diseases Intensive care medicine Kidney Glomerulus - physiopathology Lasers Male Medical sciences Microdissection Molecular Sequence Data Nephrotic Syndrome - etiology Nephrotic Syndrome - metabolism Prognosis Serum Amyloid A Protein - metabolism Tandem Mass Spectrometry Viral diseases Viral hepatitis
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Zusammenfassung:	We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).
ISSN:	0931-0509 1460-2385
DOI:	10.1093/ndt/gfr224