Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis

Background This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. Methods Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients...

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Veröffentlicht in:	Journal of gastroenterology 2011-09, Vol.46 (9), p.1111-1119
Hauptverfasser:	Hiramatsu, Naoki, Kurosaki, Masayuki, Sakamoto, Naoya, Iwasaki, Manabu, Sakamoto, Minoru, Suzuki, Yoshiyuki, Sugauchi, Fuminaka, Tamori, Akihiro, Kakinnuma, Sei, Matsuura, Kentaro, Izumi, Namiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adult Aged Anemia Anemia, Hemolytic - chemically induced Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biliary Tract Biological response modifiers Care and treatment Cohort Studies Colorectal Surgery Data mining Decision Trees Development and progression Disease Progression Dose-Response Relationship, Drug Drug Therapy, Combination Female Gastroenterology Genotype Health aspects Hemoglobin Hepacivirus - genetics Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Hepatology Hospitals Humans Interferon alpha Interferon-alpha - administration & dosage Interferon-alpha - therapeutic use Male Medicine Medicine & Public Health Middle Aged Original Article—Liver Pancreas Polyethylene Glycols - administration & dosage Polyethylene Glycols - therapeutic use Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Reproducibility of Results Retrospective Studies Ribavirin Ribavirin - administration & dosage Ribavirin - adverse effects Ribavirin - therapeutic use Severity of Illness Index Surgical Oncology
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Zusammenfassung:	Background This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. Methods Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients were randomly assigned to a model-building group ( n = 691) or an internal validation group ( n = 390). Factors predictive of severe anemia (hemoglobin, Hb
ISSN:	0944-1174 1435-5922
DOI:	10.1007/s00535-011-0412-z