Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena

Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SM...

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Veröffentlicht in:	General and comparative endocrinology 2011-05, Vol.171 (3), p.341-349
Hauptverfasser:	Kim, Mi Ae, Kim, Dong Soo, Sohn, Young Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists aldosterone Amino Acid Sequence amino acids Animals complementary DNA Coregulator cortisol dexamethasone Dexamethasone - pharmacology Endocrinology & Metabolism euryhaline species fish Freshwater Glucocorticoid receptors Hormone Antagonists - pharmacology Hydrocortisone - pharmacology Marine Medaka Mifepristone - pharmacology Molecular Sequence Data open reading frames Oryzias Oryzias - metabolism Oryzias dancena Oryzias latipes phylogeny Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism reporter genes RNA, Messenger - genetics sequence analysis Sequence Homology, Amino Acid Teleost Teleostei transcription (genetics) transcriptional activation transfection
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Zusammenfassung:	Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SMILE, modulate agonist-activated medaka GR1 and GR2. ► Medaka GR2 is a functionally closer ortholog to mammalian GRα.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2011.02.015