New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones

A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindol...

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Veröffentlicht in:	Folia microbiologica 2006, Vol.51 (1), p.25-26, Article 25
Hauptverfasser:	Waisser, K, Heinisch, L, Slosárek, M, Janota, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antitubercular Agents - pharmacology Bacteriology Indoles - chemistry Indoles - pharmacology Isoniazid - pharmacology Microbial Sensitivity Tests Microbiology Mycobacterium Mycobacterium avium Complex - drug effects Mycobacterium fortuitum - drug effects Mycobacterium kansasii - drug effects Mycobacterium tuberculosis - drug effects Nontuberculous Mycobacteria - drug effects Pathology Thiones - chemistry Thiones - pharmacology Tuberculosis
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Zusammenfassung:	A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02931445