nitrile-degrading enzymes: current status and future prospects

Nitrile-converting enzymes are becoming commonplace in the synthesis of pharmaceuticals and commodity chemicals. These versatile biocatalysts have potential applications in different fields including synthetic biocatalysis and bioremediation. This review attempts to describe in detail the three majo...

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Veröffentlicht in:	Applied microbiology and biotechnology 2002-10, Vol.60 (1/2), p.33-44
Hauptverfasser:	Banerjee, A, Sharma, R, Banerjee, U.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Aminohydrolases - metabolism Analysis Bacteria - enzymology Bacteria - genetics biocatalysis biocatalysts Biological and medical sciences Bioremediation Biotechnology Biotransformation Catalysis Chemical Industry Cloning Drug Design drugs Enzyme engineering Enzymes Forecasting Fundamental and applied biological sciences. Psychology Hydro-Lyases - chemistry Hydro-Lyases - genetics Hydro-Lyases - metabolism Hydrolases Hydrolysis mechanism of action Methods. Procedures. Technologies Microbiological synthesis Miscellaneous molecular cloning Nitriles - metabolism
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Beschreibung
Zusammenfassung:	Nitrile-converting enzymes are becoming commonplace in the synthesis of pharmaceuticals and commodity chemicals. These versatile biocatalysts have potential applications in different fields including synthetic biocatalysis and bioremediation. This review attempts to describe in detail the three major classes of nitrile-converting enzymes, namely nitrilases, nitrile hydratases and amidases. Various aspects of these enzymes including their occurrence, mechanism of action, characteristics and applicability in different sectors have been elaborately elucidated. Cloning of genes related to nitrile-converting enzymes is also discussed.
ISSN:	0175-7598 1432-0614
DOI:	10.1007/s00253-002-1062-0