Phenytoin hypersensitivity syndrome

Phenytoin hypersensitivity syndrome

Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis. In this article, we present the clinical, laboratory and histopathologic results of 5 cases of PHS....

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Veröffentlicht in:Neurological sciences 2001-06, Vol.22 (3), p.261-265
Hauptverfasser: Güngör, E, Alli, N, Comoğlu, S, Cömcüoğlu, C
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Anticonvulsants - adverse effects
Drug Hypersensitivity - complications
Drug Hypersensitivity - pathology
Eosinophilia
Eosinophilia - pathology
Epidermis - pathology
Female
Hepatitis - etiology
Humans
Leukocyte Count
Lymph Nodes - pathology
Male
Neurosciences
Phenytoin - adverse effects
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Beschreibung
Zusammenfassung:Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis. In this article, we present the clinical, laboratory and histopathologic results of 5 cases of PHS. In therapy, pheyntoin was stopped and sodium valproate (10-20 mg/kg day) was started. Additionally, prednisolone was given in two patients who had not resolved eruption with conservative therapy.
ISSN:1590-1874
1590-3478
DOI:10.1007/s100720100024