Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes

Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses thr...

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Veröffentlicht in:	Journal of neurovirology 2010-06, Vol.16 (3), p.203-207
1. Verfasser:	Mori, Isamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Alzheimer Disease - virology Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain - virology Encephalitis, Herpes Simplex - virology Gene Expression Regulation, Viral Herpes Simplex - virology Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - growth & development Human viral diseases Humans Immunology Infectious Diseases Medical sciences Mini Review Neurology Neurosciences Viral diseases Viral diseases of the nervous system Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Virology
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Zusammenfassung:	Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.
ISSN:	1355-0284 1538-2443
DOI:	10.3109/13550281003739040