Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization

DNA hybridization can finely regulate the intrinsic glucose oxidase like catalytic activity of AuNPs owing to the marked difference in adsorption of single‐ and double‐stranded DNA on its surface. A sensing strategy for DNA and microRNA is presented; in a different approach, this DNA‐regulated AuNP...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-12, Vol.50 (50), p.11994-11998
Hauptverfasser: Zheng, Xiaoxue, Liu, Qing, Jing, Chao, Li, Yang, Li, Di, Luo, Weijie, Wen, Yanqin, He, Yao, Huang, Qing, Long, Yi-Tao, Fan, Chunhai
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container_end_page 11998
container_issue 50
container_start_page 11994
container_title Angewandte Chemie International Edition
container_volume 50
creator Zheng, Xiaoxue
Liu, Qing
Jing, Chao
Li, Yang
Li, Di
Luo, Weijie
Wen, Yanqin
He, Yao
Huang, Qing
Long, Yi-Tao
Fan, Chunhai
description DNA hybridization can finely regulate the intrinsic glucose oxidase like catalytic activity of AuNPs owing to the marked difference in adsorption of single‐ and double‐stranded DNA on its surface. A sensing strategy for DNA and microRNA is presented; in a different approach, this DNA‐regulated AuNP catalysis was coupled with AuNP‐mediated seed growth, which was monitored in real time and at a single‐nanoparticle level.
doi_str_mv 10.1002/anie.201105121
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Catalysis
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
Glucose oxidase
Gold - chemistry
gold nanoparticles
Humans
Joining
Metal Nanoparticles - chemistry
Microscopy
Microscopy, Confocal
Nanoparticles
nanoplasmonics
Nanostructure
Nucleic Acid Hybridization - methods
Real time
Strategy
Surface chemistry
title Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization
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