Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization

Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization

DNA hybridization can finely regulate the intrinsic glucose oxidase like catalytic activity of AuNPs owing to the marked difference in adsorption of single‐ and double‐stranded DNA on its surface. A sensing strategy for DNA and microRNA is presented; in a different approach, this DNA‐regulated AuNP...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-12, Vol.50 (50), p.11994-11998
Hauptverfasser: Zheng, Xiaoxue, Liu, Qing, Jing, Chao, Li, Yang, Li, Di, Luo, Weijie, Wen, Yanqin, He, Yao, Huang, Qing, Long, Yi-Tao, Fan, Chunhai
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
Glucose oxidase
Gold - chemistry
gold nanoparticles
Humans
Joining
Metal Nanoparticles - chemistry
Microscopy
Microscopy, Confocal
Nanoparticles
nanoplasmonics
Nanostructure
Nucleic Acid Hybridization - methods
Real time
Strategy
Surface chemistry
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Zusammenfassung:DNA hybridization can finely regulate the intrinsic glucose oxidase like catalytic activity of AuNPs owing to the marked difference in adsorption of single‐ and double‐stranded DNA on its surface. A sensing strategy for DNA and microRNA is presented; in a different approach, this DNA‐regulated AuNP catalysis was coupled with AuNP‐mediated seed growth, which was monitored in real time and at a single‐nanoparticle level.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201105121