Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2012-01, Vol.10 (1), p.67-69
Hauptverfasser:	Gignoux, Camille, Newton, Annabella F, Barthelme, Alexandre, Lewis, William, Alcaraz, Marie-Lyne, Stockman, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Spiro Compounds - chemical synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c1ob06380d