A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae

Genes that are essential for growth in yeast were screened to identify those involved in arsenite sensitivity. We found that the knockdown of YPT1, ERG8, or RKI1 enhanced arsenite sensitivity in yeast.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of toxicological sciences 2011/12/01, Vol.36(6), pp.859-861
Hauptverfasser:	Takahashi, Tsutomu, Satake, Shohei, Hirose, Ken-ichiro, Hwang, Gi-Wook, Naganuma, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldose-Ketose Isomerases - genetics Arsenite Arsenites - toxicity ERG8 Gene Expression Regulation, Fungal Gene Knockdown Techniques Genes, Essential - genetics Genes, Fungal - genetics Phosphotransferases (Phosphate Group Acceptor) - genetics rab GTP-Binding Proteins - genetics Real-Time Polymerase Chain Reaction RKI1 Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins - genetics Sensitivity Toxicity Yeast Yeasts YPT1
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Beschreibung
Zusammenfassung:	Genes that are essential for growth in yeast were screened to identify those involved in arsenite sensitivity. We found that the knockdown of YPT1, ERG8, or RKI1 enhanced arsenite sensitivity in yeast.
ISSN:	0388-1350 1880-3989
DOI:	10.2131/jts.36.859