Larrealignans A and B, Novel Lignan Glycosides from the Aerial Parts of Larrea tridentata

Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated comp...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2011/12/01, Vol.59(12), pp.1467-1470
Hauptverfasser:	Yokosuka, Akihito, Matsuo, Yukiko, Jitsuno, Maki, Adachi, Kohei, Mimaki, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology cytotoxic activity Drug Screening Assays, Antitumor HL-60 Cells Humans Larrea - chemistry Larrea tridentata Leukemia - drug therapy lignan lignan glycoside Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Plant Components, Aerial - chemistry Spectrum Analysis Zygophyllaceae
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Zusammenfassung:	Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds (1—3) and aglycones (1a, 2a) of 1 and 2 were evaluated for their cytotoxic activities against HL-60 human leukemia cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.59.1467