Salt concentration-induced dehybridisation of DNA-gold nanoparticle conjugate assemblies for diagnostic applications

We present the cooperative dehybridisation of DNA-gold nanoparticle conjugate (DNA-AuNP) assemblies induced by reduced salt concentration ([salt]), which can be precisely controlled by various conditions. The detection of Ag(+) based upon the [salt]-induced dehybridisation of DNA-AuNP assemblies is...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-09, Vol.46 (34), p.6382-6384
Hauptverfasser:	Oh, Ju-Hwan, Lee, Jae-Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry Gold - chemistry Metal Nanoparticles - chemistry Silver - analysis Sodium Chloride - chemistry
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Zusammenfassung:	We present the cooperative dehybridisation of DNA-gold nanoparticle conjugate (DNA-AuNP) assemblies induced by reduced salt concentration ([salt]), which can be precisely controlled by various conditions. The detection of Ag(+) based upon the [salt]-induced dehybridisation of DNA-AuNP assemblies is five times more sensitive than that achieved under conventional thermal melting conditions.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c0cc01488e