The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions
The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of sim...
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| Veröffentlicht in: | Green chemistry : an international journal and green chemistry resource : GC 2003-01, Vol.5 (4), p.477-479 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions. |
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| ISSN: | 1463-9262 1463-9270 |
| DOI: | 10.1039/B306242B |