Synthesis of Quinolines, Pyridine Ligands and Biological Probes in Green Media

Although water provides an environmentally friendly and low-cost reaction solvent for organic synthesis, many organic compounds exhibit poor solubility in water. A study is described in which researchers prepared samples of nitrogen heterocycles using pressurized water under microwave and thermal co...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2003-01, Vol.5 (2), p.177-177
Hauptverfasser: Bryson, T A, Gibson, J M, Stewart, J J, Voegtle, H, Tiwari, A, Dawson, J H, Marley, W
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Sprache:eng
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Zusammenfassung:Although water provides an environmentally friendly and low-cost reaction solvent for organic synthesis, many organic compounds exhibit poor solubility in water. A study is described in which researchers prepared samples of nitrogen heterocycles using pressurized water under microwave and thermal conditions. Findings from the study indicated that several desirable reactions were developed in water or water-protic solvent media, including selective reduction, cyclodehydration (Friedlander and Pfitzinger synthesis), Suzuki coupling, and ligand exchange.
ISSN:1463-9262
DOI:10.1039/b211968d