Isariotins G–J from cultures of the Lepidoptera pathogenic fungus Isaria tenuipes

Four new alkaloids isariotins G–J ( 1– 4), together with the known isariotins, were isolated from the Lepidoptera pathogenic fungus Isaria tenuipes. These compounds exhibited antimalarial and cytotoxic activities. [Display omitted] ► Four new alkaloids, isariotions G–J, were isolated from cultures of Isaria tenuipes. ► The structures were elucidated on the basis of spectroscopic data. ► Isariotins exhibited antimalarial and cytotoxic activities. Four new alkaloids isariotins G–J ( 1– 4), together with the known isariotins, were isolated from cultures of the Lepidoptera pathogenic fungus Isaria tenuipes. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Compounds 1– 4 exhibited antimalarial and cytotoxic activities.