The incidence of heterogeneous vancomycin-intermediate Staphylococcus aureus correlated with increase of vancomycin MIC

Abstract A total of 559 methicillin-resistant Staphylococcus aureus isolates were investigated for heterogeneous vancomycin-intermediate S. aureus (hVISA) by population analysis profile area under the curve. Our results suggested that the incidence of hVISA increased rapidly when vancomycin MIC shif...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2011-11, Vol.71 (3), p.301-303
Hauptverfasser:	Chen, Hongbin, Liu, Yudong, Sun, Wenjia, Chen, Minjun, Wang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Heterogeneous vancomycin-intermediate S. aureus Humans Incidence Infectious Disease Infectious diseases Internal Medicine Medical sciences Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Microbiology Miscellaneous MRSA Staphylococcal Infections - epidemiology Staphylococcus aureus Vancomycin Vancomycin - pharmacology Vancomycin Resistance
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Zusammenfassung:	Abstract A total of 559 methicillin-resistant Staphylococcus aureus isolates were investigated for heterogeneous vancomycin-intermediate S. aureus (hVISA) by population analysis profile area under the curve. Our results suggested that the incidence of hVISA increased rapidly when vancomycin MIC shifted from 1 to 2 μg/mL, and at vancomycin MIC of 2 μg/mL, the incidence of hVISA was nearly 40%.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2011.06.010