Detection of TFPI2 methylation in the serum of colorectal cancer patients

Highlights ► Thirty-nine of 215 patients exhibited TFPI2 methylation in their serum DNA. ► TFPI2 methylation was observed more frequently according to the cancer progression. ► Using three serum markers including TFPI2 methylation, the detection rate was 42%.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2011-12, Vol.311 (1), p.96-100
Hauptverfasser:	Hibi, Kenji, Goto, Tetsuhiro, Shirahata, Atsushi, Saito, Mitsuo, Kigawa, Gaku, Nemoto, Hiroshi, Sanada, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - genetics blood serum carcinoma Cell Differentiation Colorectal cancer colorectal neoplasms Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Deoxyribonucleic acid DNA DNA Methylation Female Gene expression Genetic testing Glycoproteins - genetics Hematology, Oncology and Palliative Medicine Humans lymph nodes Male metastasis Methylation Middle Aged Mitochondrial DNA patients polymerase chain reaction screening Studies TFPI2 Tumors
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Beschreibung
Zusammenfassung:	Highlights ► Thirty-nine of 215 patients exhibited TFPI2 methylation in their serum DNA. ► TFPI2 methylation was observed more frequently according to the cancer progression. ► Using three serum markers including TFPI2 methylation, the detection rate was 42%.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.07.006