In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

We investigated anti-inflammatory activity of a major ellagitannin metabolite urolithin A on carrageenan-induced paw edema in mice and antioxidant activity of urolithin A in mouse plasma after the oral administration by the ORAC assay. Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.