Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system

Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in D...

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Veröffentlicht in:	Microbes and infection 2010-10, Vol.12 (11), p.799-808
Hauptverfasser:	Bloemers, Beatrijs L.P., Broers, Chantal J.M., Bont, Louis, Weijerman, Michel E., Gemke, Reinoud J.B.J., van Furth, A. Marceline
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Biological and medical sciences Down syndrome Down Syndrome - complications Down Syndrome - immunology Fundamental and applied biological sciences. Psychology Humans Immune System - physiopathology Immunology Infant, Newborn Innate immunity Microbiology Respiratory tract infections Respiratory Tract Infections - epidemiology Respiratory Tract Infections - immunology Risk Assessment
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Beschreibung
Zusammenfassung:	Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2010.05.007