Differential expression of PTHrP and its receptor in pituitary gland and gills in estradiol-treated gilthead sea bream ( Sparus auratus , L.)

Highlights ► In gilthead sea bream PTHrP mediates E2 -induced hypercalcemia. ► E2 -treated sea bream become hypercalcemic and have elevated plasma PTHrP. ► mRNA’s of PTHrP and PTH1R are upregulated in gills, downregulated in hypophysis. ► PTHrP mediates in E2 -induced hypercalcemia. ► We define an e...

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Veröffentlicht in:	General and comparative endocrinology 2011-08, Vol.173 (1), p.199-204
Hauptverfasser:	Bevelander, Gideon S, Guerreiro, Pedro M, Spanings, Tom, Flik, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals calcium Endocrinology & Metabolism Estradiol Estradiol - pharmacology gene expression regulation genes Gill gills Gills - drug effects Gills - metabolism hypercalcemia Hypercalcemia - chemically induced Hypercalcemia - metabolism Marine messenger RNA parathyroid hormone Parathyroid Hormone-Related Protein - genetics Parathyroid Hormone-Related Protein - metabolism Pituitary gland Pituitary Gland - drug effects Pituitary Gland - metabolism PTH1R PTHrP Receptor, Parathyroid Hormone, Type 1 - genetics Receptor, Parathyroid Hormone, Type 1 - metabolism Reverse Transcriptase Polymerase Chain Reaction Sea bream Sea Bream - metabolism Sparus aurata vitellogenesis vitellogenin
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Zusammenfassung:	Highlights ► In gilthead sea bream PTHrP mediates E2 -induced hypercalcemia. ► E2 -treated sea bream become hypercalcemic and have elevated plasma PTHrP. ► mRNA’s of PTHrP and PTH1R are upregulated in gills, downregulated in hypophysis. ► PTHrP mediates in E2 -induced hypercalcemia. ► We define an endocrine pituitary PTHrP system and a branchial paracrine PTHrP system.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2011.05.017